Tuesday, February 21, 2012

Why I am a BIGBOD!

This article states that I am a bigbod because... I am a girl. DAS RIGHTTTT!!!!!
This article talks about how women have stronger immune systems than men. This is because it is X-linked (as we have talked about in this chapter). Dr. Claude Libert from Ghent University in Belgium researched MicroRNA (short ribonucleic acid molecule found in eukaryotic cells that has very few nucleotides compared with other RNAs). Why microRNA? Perhaps because it is essential for all known forms of life.
"Statistics show that in humans, as with other mammals, females live longer than males and are more able to fight off shock episodes from sepsis (presence in tissues of harmful bacteria and their toxins, typically through infection of a wound), infection, or trauma", stated Libert. He claims this is because the X chromosome has 10% of all microRNA's known so far in the genome. This may be because many X chromosome- located strands of microRNA play important roles in cancer and immunity.
Dr. Libert's research states that there are biological mechanisms present on the X chromosome that play major roles on individuals' genes. Aka imprinting; and thus giving immunological advantages to females :) DAS WASSUPPPPPPP.


Le "X chromosome"




Libert's hypothesis states that he believes the immunological advantage that is present, is due to the silencing of X-linked genes by the microRNAs. "Gene silencing and inactivation skewing are known mechanisms which affect X-linked genes and may influence X-linked microRNA's in the same way"
In sum, I am a bigbod because I obvs have two X chromosomes. On the other hand, males have one X chromosome. Y chromosomes have fewer genes so if the genes involved in immunity are silenced maternally, that guy is screwed because he wouldn't have any back-up genetic information. 
Now go cry cause I'm a girl and a bigbod, and you're not!

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