This article is about how protein synthesis accounts for many components necessary to the cell. But along with protein synthesis compartmentalization is necessary. This article talks about how proteins know where to go in a cell, how they get to their specific destinations, how there is a chance for errors, and what diseases those errors might cause. The article mentions a couple of diseases that arise from defective protein folding, and failures of the cell's quality control center.
One disease that may result from conformational errors is Alzheimer's Disease. Conformational diseases arise when a protein changes size or shape and tissue disposition occurs as amyloid fibrils. Alzheimer's specifically results when a specific protein undergoes a conformational rearrangement that results in aggregation and deposition within tissues. Alzheimer's has occasional patterns such as appearing later in life and causing neuronal loss and synaptic abnormalities.
Alzheimer's itself is the most common form of dementia. You gradually lose your memory, and your brain functions and behavior start to deteriorate.
Relating to trafficking, what causes Alzheimer's is extracellular plaques and intracellular neurofibrillary tangles. Extracellular plaques are primarily made up of amyloid-β-peptide and tangles are made of cytoskeleton proteins.
Another disease and second most common neurodegenerative disorder is Parkinson's Disease. Parkinson's is the degeneration of dopaminergic neurons in the substantia nigra. Parkinson's will give you muscular rigidity, postural instability, and a resting tremor. It is caused by deposition in brain cells of intracytoplasmic inclusion bodies, Lewy bodies.
One disease that may result from conformational errors is Alzheimer's Disease. Conformational diseases arise when a protein changes size or shape and tissue disposition occurs as amyloid fibrils. Alzheimer's specifically results when a specific protein undergoes a conformational rearrangement that results in aggregation and deposition within tissues. Alzheimer's has occasional patterns such as appearing later in life and causing neuronal loss and synaptic abnormalities.
Alzheimer's itself is the most common form of dementia. You gradually lose your memory, and your brain functions and behavior start to deteriorate.
Relating to trafficking, what causes Alzheimer's is extracellular plaques and intracellular neurofibrillary tangles. Extracellular plaques are primarily made up of amyloid-β-peptide and tangles are made of cytoskeleton proteins.
Another disease and second most common neurodegenerative disorder is Parkinson's Disease. Parkinson's is the degeneration of dopaminergic neurons in the substantia nigra. Parkinson's will give you muscular rigidity, postural instability, and a resting tremor. It is caused by deposition in brain cells of intracytoplasmic inclusion bodies, Lewy bodies.
No comments:
Post a Comment